Evidence Explorer / Collection
CANCER-SPECIFIC COLLECTIONS
Begin with the diagnosis
Seven cancer-specific routes plus cross-cancer resources. These collections organize the current coverage; absence of a topic is a coverage gap, not proof that nothing has been studied.
Breast cancer
- Cooling gloves & socks — Mixed evidence
- Melatonin for sleep — Small randomized signal
- Oxybutynin for hot flashes — Short-term randomized benefit
- PREFERABLE-EFFECT: exercise with metastatic breast cancer — Modest randomized benefit for fatigue and quality of life
- Vitamin B6 for hand–foot syndrome — No demonstrated benefit
- Yoga after treatment — Supportive randomized evidence
- Scalp cooling — Randomized benefit for a specific goal
- Curcumin for radiation skin reactions — Oral negative; topical uncertain
- Strength training with lymphedema — Supportive randomized evidence
- CBT-I — Guideline-supported
- Vitamin D for AI joint pain — No consistent symptom benefit
- Mindfulness for anxiety — Guideline-supported
- Alpha-lipoic acid for chemotherapy neuropathy — Benefit not established
- Tart cherry for AI joint pain — Small randomized signal
- Acetyl-L-carnitine for taxane neuropathy — Harm signal
- Acupuncture for AI joint pain — Guideline-supported option
See every breast cancer article →
Colorectal cancer
- Colorectal surgery prehabilitation — Positive complication signal
- Vitamin B6 for hand–foot syndrome — No demonstrated benefit
- Oral cryotherapy / ice chips — Guideline-supported settings
- Structured exercise after colon cancer — Positive phase III evidence
- Alpha-lipoic acid for chemotherapy neuropathy — Benefit not established
- St. John’s wort and irinotecan — Documented interaction
See every colorectal cancer article →
Pancreatic cancer
- Omega-3s for weight loss — Inconsistent evidence
- L-glutamine in pancreatic cancer — Early-phase investigational
- IV vitamin C in pancreatic cancer — Investigational randomized signal
See every pancreatic cancer article →
Lung cancer
- Lung surgery prehabilitation — Positive randomized signal
See every lung cancer article →
Head and neck cancer
- Zinc for taste changes — No consistent benefit
- Acupuncture for dry mouth — Modest randomized benefit
See every head and neck cancer article →
Ovarian cancer
- Fasting around treatment — Investigational
See every ovarian cancer article →
Prostate cancer
- Exercise during ADT — Supportive randomized evidence
- Pelvic-floor training — Mixed rehabilitation evidence
See every prostate cancer article →
Across cancer types
Many fatigue, sleep, nausea and safety questions are shared. Applicability still depends on the treatment, stage, health status and exact intervention.
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New cancer-linked routes
- Breast cancer: CoQ10 for fatigue; hypnosis for hot flashes; acupuncture for AI joint pain.
- Breast and gastrointestinal cancers using capecitabine: topical diclofenac for hand–foot syndrome prevention.
- Cross-cancer advanced disease and wasting: creatine for weight, lean mass and function.
These links answer supportive-care questions. They do not establish tumor response, recurrence prevention or survival benefit.
New cancer-specific routes — October 14
- Breast: Soy foods after breast cancer; Self-acupressure for persistent fatigue after breast cancer.
- Colorectal: Individualized dietary counseling during radiotherapy; High-dose vitamin D with chemotherapy for metastatic colorectal cancer.
- Head and neck: Individualized dietary counseling during radiotherapy; Photobiomodulation for oral mucositis.
- Gastrointestinal surgery: Perioperative immunonutrition for gastrointestinal cancer surgery.
- Cervical and endometrial: Selenium during pelvic radiotherapy.
- Prostate: High-vegetable diet during prostate-cancer active surveillance; Pomegranate products for prostate-cancer progression.
- Acute leukemia and stem-cell transplant: Neutropenic diets during leukemia treatment and stem-cell transplant.
New cancer-specific routes — October 15, 2026
- Breast: Black cohosh for hot flashes after breast cancer; Calendula ointment for breast-radiotherapy skin reactions; Vitamin E for hot flashes after breast cancer; Milk thistle for chemotherapy-associated liver injury.
- Head and neck: Guarana for cancer-related fatigue; Aloe vera gel for radiation dermatitis; Oral L-glutamine for treatment-related oral mucositis.
- Colorectal and other gastrointestinal: Chamomile mouthwash for treatment-related oral mucositis; Intravenous glutathione to prevent platinum neuropathy; Goshajinkigan to prevent oxaliplatin neuropathy.
- Leukemia and stem-cell transplant: Chamomile mouthwash for treatment-related oral mucositis; Milk thistle for chemotherapy-associated liver injury.
- Cross-cancer supportive care: Guarana for cancer-related fatigue; Aloe vera gel for radiation dermatitis; Intravenous glutathione to prevent platinum neuropathy; Oral L-glutamine for treatment-related oral mucositis.
New cancer-specific routes — October 16, 2026
- Breast: structured postoperative physiotherapy; exercise during neoadjuvant chemotherapy; exercise for cognitive changes; manual lymph drainage for lymphedema prevention; exercise for insomnia during chemotherapy.
- Head and neck: exercise prehabilitation before chemoradiotherapy; preventive swallowing exercises during radiotherapy.
- Prostate: lesion-aware exercise with bone metastases.
- Ovarian: aerobic exercise for persistent chemotherapy neuropathy.
- Hematologic malignancy / transplant: exercise during allogeneic stem-cell transplantation.
Cancer-specific additions — October 17, 2026
Breast cancer
- Tai Chi Chih for insomnia after breast cancer
- Morning bright light for fatigue during chemotherapy
- Mindfulness-based programs for post-treatment fatigue
- Yoga during radiotherapy for quality of life
Renal cell carcinoma
Mixed cancer populations and survivorship
- Music therapy compared with CBT for survivor anxiety
- Acupuncture compared with CBT-I for survivor insomnia
- Progressive relaxation plus guided imagery during chemotherapy
Advanced illness and end-of-life care
Cancer-specific additions · October 18, 2026
- Breast cancer: acupuncture for fatigue; electroacupuncture for hot flashes; reflexology for symptoms in advanced disease; scalp cooling
- Head and neck cancer: acupuncture for chronic radiation-related dry mouth
- Across cancers: acupuncture for chemotherapy neuropathy; acupuncture for survivor pain; P6 wristbands for nausea; oral cryotherapy; limb cryotherapy
These routes describe supportive-care outcomes only. Cancer type, stage, treatment and eligibility still need to match the source population.
Cancer routes added October 19
- Breast cancer: curcumin with tamoxifen; antioxidants during chemotherapy.
- Head and neck cancer: high-dose antioxidant vitamins during radiotherapy.
- Melanoma / immunotherapy: probiotic supplements; cannabis use.
- Skin cancer: black salve.
- Multiple cancer types / broad claims: grapefruit interactions; Essiac/Flor Essence; Gerson therapy; chlorine dioxide/MMS.
